{
  "data": {
    "__count": 1,
    "__licence": {
      "identifier": "CC-BY-4.0",
      "link": "https://creativecommons.org/licenses/by/4.0",
      "name": "Creative Commons Attribution 4.0 International"
    },
    "results": {
      "Date": "2026-06-23 07:57:58",
      "DisorderGroup": "Disorder",
      "ORPHAcode": 3380,
      "OrphanetURL": "http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=en&Expert=3380",
      "Preferred term": "Trisomy 18 syndrome",
      "Prevalence": [
        {
          "PrevalenceClass": "1-5 / 10 000",
          "PrevalenceGeographic": "Worldwide",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Not yet validated",
          "Source": "23088440[PMID]",
          "ValMoy": "16.7"
        },
        {
          "PrevalenceClass": "1-9 / 100 000",
          "PrevalenceGeographic": "Austria",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2007[OTHER]",
          "ValMoy": "9.8"
        },
        {
          "PrevalenceClass": "1-9 / 100 000",
          "PrevalenceGeographic": "Hungary",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2010[OTHER]",
          "ValMoy": "4.4"
        },
        {
          "PrevalenceClass": "1-5 / 10 000",
          "PrevalenceGeographic": "Ireland",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2010[OTHER]",
          "ValMoy": "25.3"
        },
        {
          "PrevalenceClass": "1-9 / 100 000",
          "PrevalenceGeographic": "Italy",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2010[OTHER]",
          "ValMoy": "4.1"
        },
        {
          "PrevalenceClass": "1-5 / 10 000",
          "PrevalenceGeographic": "Netherlands",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2010[OTHER]",
          "ValMoy": "11.4"
        },
        {
          "PrevalenceClass": "1-5 / 10 000",
          "PrevalenceGeographic": "Norway",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2010[OTHER]",
          "ValMoy": "11.2"
        },
        {
          "PrevalenceClass": "1-9 / 100 000",
          "PrevalenceGeographic": "Europe",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "22713804[PMID]_EUROCAT European surveillance of congenital anomalies 2005-2009[OTHER]",
          "ValMoy": "10.4"
        },
        {
          "PrevalenceClass": "1-9 / 1 000 000",
          "PrevalenceGeographic": "Europe",
          "PrevalenceQualification": "Class only",
          "PrevalenceType": "Point prevalence",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2005-2009[OTHER]",
          "ValMoy": "0.0"
        },
        {
          "PrevalenceClass": "1-9 / 100 000",
          "PrevalenceGeographic": "France",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2010[OTHER]",
          "ValMoy": "5.8"
        },
        {
          "PrevalenceClass": "1-9 / 100 000",
          "PrevalenceGeographic": "Belgium",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2009[OTHER]",
          "ValMoy": "8.9"
        },
        {
          "PrevalenceClass": "1-9 / 100 000",
          "PrevalenceGeographic": "Germany",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2010[OTHER]",
          "ValMoy": "5.8"
        },
        {
          "PrevalenceClass": "1-5 / 10 000",
          "PrevalenceGeographic": "Malta",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2009[OTHER]",
          "ValMoy": "48.2"
        },
        {
          "PrevalenceClass": "1-9 / 100 000",
          "PrevalenceGeographic": "Poland",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2010[OTHER]",
          "ValMoy": "4.4"
        },
        {
          "PrevalenceClass": "1-9 / 100 000",
          "PrevalenceGeographic": "Portugal",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2010[OTHER]",
          "ValMoy": "9.5"
        },
        {
          "PrevalenceClass": "1-9 / 100 000",
          "PrevalenceGeographic": "Spain",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2010[OTHER]",
          "ValMoy": "1.9"
        },
        {
          "PrevalenceClass": "1-5 / 10 000",
          "PrevalenceGeographic": "Switzerland",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2010[OTHER]",
          "ValMoy": "24.6"
        },
        {
          "PrevalenceClass": "1-5 / 10 000",
          "PrevalenceGeographic": "United Kingdom",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "20384468 [PMID]_ORPHANET",
          "ValMoy": "13.0"
        },
        {
          "PrevalenceClass": "1-9 / 100 000",
          "PrevalenceGeographic": "Ukraine",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2010[OTHER]",
          "ValMoy": "6.5"
        },
        {
          "PrevalenceClass": "1-5 / 10 000",
          "PrevalenceGeographic": "Croatia",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2010[OTHER]",
          "ValMoy": "14.6"
        },
        {
          "PrevalenceClass": "1-5 / 10 000",
          "PrevalenceGeographic": "Denmark",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "EUROCAT European surveillance of congenital anomalies 2009[OTHER]",
          "ValMoy": "38.8"
        },
        {
          "PrevalenceClass": "1-5 / 10 000",
          "PrevalenceGeographic": "Japan",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "2092586[PMID]",
          "ValMoy": "18.0"
        },
        {
          "PrevalenceClass": "1-5 / 10 000",
          "PrevalenceGeographic": "Japan",
          "PrevalenceQualification": "Class only",
          "PrevalenceType": "Point prevalence",
          "PrevalenceValidationStatus": "Validated",
          "Source": "2092586[PMID]",
          "ValMoy": "0.0"
        },
        {
          "PrevalenceClass": "1-5 / 10 000",
          "PrevalenceGeographic": "United States",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Not yet validated",
          "Source": "ORPHANET_18348276[PMID]_20878909[PMID]",
          "ValMoy": "19.1"
        },
        {
          "PrevalenceClass": "1-5 / 10 000",
          "PrevalenceGeographic": "Specific population",
          "PrevalenceQualification": "Value and class",
          "PrevalenceType": "Prevalence at birth",
          "PrevalenceValidationStatus": "Validated",
          "Source": "10627940[PMID]",
          "ValMoy": "12.6"
        }
      ],
      "Typology": "Malformation syndrome"
    }
  },
  "datasetCategory": {
    "lang": "en",
    "name": "Epidemiology of rare diseases"
  },
  "parameters": {
    "path": {
      "ORPHAcode": 3380
    },
    "query": {}
  },
  "uri": "https://api.orphadata.com/rd-epidemiology/orphacodes/3380"
}